Spring Anime Kusuriya no Hitorigoto: Maomao Angers Shenmei, Taken to Torture Chamber… Episode 45 Preview Cuts

We’ve got some advance cuts and the synopsis for the upcoming 45th episode of the Spring 2025 anime Kusuriya no Hitorigoto Season 2 Second Cour, titled “Hikibabon”, airing on Friday, June 6th, 2025.

Kusuriya no Hitorigoto Episode 45 'Hikibabon' Advance Cut

TV Anime Kusuriya no Hitorigoto Season 2 Second Cour Key Visual

Kusuriya no Hitorigoto is a palace mystery entertainment series based on the novel series by Hinata Natsu, published under Hero Bunko by Imagica Infos and also serialized as manga in Big Gangan and Sunday GX magazines. The series has surpassed a cumulative total of 40 million copies in print. Set in a medieval East Asian-inspired world, it follows Maomao, a young girl who serves as a “poison taster” and solves various challenging cases occurring within the palace.

The second season, which began airing in January 2025, has garnered significant attention, consistently ranking high on various streaming platforms. Furthermore, the first-ever exhibition, “TV Anime Kusuriya no Hitorigoto Exhibition,” started on March 26th, and a collaboration event with Universal Studios Japan is planned for this summer, adding to the excitement around the series.


Episode 45 “Hikibabon” Synopsis

Kusuriya no Hitorigoto Episode 45 'Hikibabon' Advance Cut

Following Jinmei’s orders, Maomao continues her days focused on creating an elixir for immortality.

Kusuriya no Hitorigoto Episode 45 'Hikibabon' Advance Cut

One day, Kyouu devises a plan to help Maomao escape, but they are quickly discovered by the guards.

Kusuriya no Hitorigoto Episode 45 'Hikibabon' Advance Cut

Surei steps in to mediate the commotion, and just as everyone breathes a sigh of relief, Jinmei appears, changing the atmosphere completely. Annoyed by Jinmei’s enjoyment in tormenting Maomao, Kyouu, Surei, and the guards, Maomao unintentionally utters a certain phrase.

Kusuriya no Hitorigoto Episode 45 'Hikibabon' Advance Cut

Enraged, Jinmei commands that Maomao be taken to the torture chamber.

Kusuriya no Hitorigoto Season 2 Second Cour Episode 45 “Hikibabon” airs from 24:05 JST on Friday, June 6th, 2025, as part of Nihon TV Kei’s “FRIDAY ANIME NIGHT (Fura Ani)” block, broadcasting simultaneously nationwide.

It will also be available on various streaming platforms sequentially after the broadcast ends.

*Broadcast dates and times are subject to change without notice.


Broadcast Information

■Kusuriya no Hitorigoto

Every Friday night from 11:00 PM JST on Nihon TV Kei’s “FRIDAY ANIME NIGHT (Fura Ani)” block, broadcasting simultaneously nationwide!

Also scheduled for sequential distribution on various streaming platforms after the broadcast ends!
※Broadcast dates and times are subject to change without notice.


Staff

Role Name
Original Work Hinata Natsu (Hero Bunko/Imagica Infos)
Original Character Design Shino Touko
Chief Director/Series Composition Naganuma Norihiro
Director Fudesaka Akifumi
Assistant Director Nakagawa Kou
Script Kakihara Yuuko
Script Chiba Misuzu
Script Ogawa Hitomi
Character Design Nakaya Yukiko
Art Director Takao Katsumi (ARED)
Color Design Aida Misato
CGI Director Nagai Yuu
Cinematography Director Suzuki Mayo (T2 studio)
Editing Imai Daisuke
Sound Director Hata Shouji (Sound Team Donfan)
Music Kousaki Satoru
Music Kevin Penkin
Music Okehazama Arisa
Second Cour Opening Theme Mrs. GREEN APPLE「Kusushiki」
Second Cour Ending Theme Omoinotake「Hitorigoto」
Animation Production TOHO animation STUDIO×OLM
Production 「Kusuriya no Hitorigoto」Production Committee

Cast

Character Voice Actor
Maomao Yuuki Aoi
Jinshi Ootsuka Takeo
Gaoshun Konishi Katsuyuki
Gyokuyouhi Tanezaki Atsumi
Rihakahi Ishikawa Yui
Jushihime Kino Hina
Shaolan Kuno Misaki
Shisui Seto Asami
Narration Shimamoto Sumi

(C) Hinata Natsu・Imagica Infos/「Kusuriya no Hitorigoto」Production Committee

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