Get Ready for the Climax! Kusuriya no Hitorigoto Season 2 Episode 48 “Hajimari” Synopsis and Preview Cuts Revealed!
For the Spring 2025 anime season, the popular series Kusuriya no Hitorigoto (also known as The Apothecary Diaries) is set to reach its exciting conclusion! The synopsis and preview cuts for the final episode of Season 2’s second cour, Episode 48 titled “Hajimari” (meaning “Beginning”), airing on Friday, July 4th, 2025, have just been released, giving fans a peek at what’s to come.
Kusuriya no Hitorigoto is based on the highly acclaimed novel series by Hyuuga Natsu, published by Hero Bunko (Imagic Infos). This captivating story, which has captivated readers with over 40 million copies sold across the series, is also serialized as a manga in Big Gangan and Sunday GX. It’s a thrilling harem mystery-solving entertainment series set in a medieval Eastern-inspired imperial court. The narrative follows Maomao, a young woman with a deep fascination for poisons and medicine, who finds herself working as a poison taster and cleverly solves intricate cases within the palace walls.
The TV anime’s second season, which premiered in January 2025, has continued to garner immense attention, consistently ranking high on various streaming platforms. The second cour began its broadcast in April, keeping fans eagerly engaged. The series’ popularity was recently highlighted at the “Fans are Passionate About This Anime/Manga Award” announced in May, where Kusuriya no Hitorigoto impressively won grand prizes in two categories: Best Currently Airing Anime and Best Theme Song for the first cour’s opening theme, “Hyakka Ryouran” by Ikuta Lilas. Adding to its accolades, the series also celebrated a double win at the “TikTok First Half Trend Awards 2025,” taking home both the Manga/Anime Category Award and the Grand Prize. With such momentum, anticipation is high for the final episode!
Episode 48 “Hajimari” (Beginning) Synopsis
As dawn breaks following the suppression of the Family of Ko, Jinshi arrives to find Maomao sleeping alongside the children who were brought out from the fortress.
While mutually expressing concern for each other’s injuries, they both begin to reflect on what Rouran protected and entrusted with her life.
Kusuriya no Hitorigoto Season 2’s second cour, Episode 48 “Hajimari”, is scheduled to air on Friday, July 4th, at 23:00 JST on the Nippon TV network as part of the “FRIDAY ANIME NIGHT (FuraAni)” programming block, broadcasting simultaneously nationwide in Japan! The episode is also planned for sequential distribution on various streaming platforms after the television broadcast concludes. Please note that broadcast dates and times are subject to change without notice.
TV Anime Kusuriya no Hitorigoto Work Overview
【Broadcast Information】
TV Anime Kusuriya no Hitorigoto
Every Friday at 23:00 JST on Nippon TV Network “FRIDAY ANIME NIGHT (FuraAni)” with nationwide simultaneous broadcast!
Also planned for sequential distribution on various streaming platforms after the broadcast ends!
*Broadcast dates and times are subject to change without notice.
Staff
| Role | Name |
|---|---|
| Original Work | Hyuuga Natsu (Hero Bunko / Imagic Infos) |
| Original Character Design | Shinotoko |
| Chief Director / Series Composition | Naganuma Norihiro |
| Director | Fudesaka Akinori |
| Assistant Director | Nakagawa Kou |
| Script | Kakihara Yuuko・Chiba Misuzu・Ogawa Hitomi |
| Character Design | Nakatani Yukiko |
| Art Director | Takao Katsumi (ARED) |
| Color Design | Aida Misato |
| CGI Director | Nagai Yuu |
| Photography Director | Suzuki Mayo (T2 studio) |
| Editing | Imai Daisuke |
| Sound Director | Hata Shouji (Sound Team Donfan) |
| Music | Kanzaki Satoru・Kevin Penkin・Okihazama Arisa |
| 2nd Cour Opening Theme | Mrs. GREEN APPLE “Kusushiki” |
| 2nd Cour Ending Theme | Omoinotake “Hitorigoto” |
| Animation Production | TOHO animation STUDIO×OLM |
| Production | “Kusuriya no Hitorigoto” Production Committee |
Cast
| Character | Voice Actor |
|---|---|
| Maomao | Yuuki Aoi |
| Jinshi | Ootsuka Takeo |
| Koushun | Konishi Katsuyuki |
| Gyokuyouhi | Tanezaki Atsumi |
| Rikahi | Ishikawa Yui |
| Rishuhi | Kino Hina |
| Shaoran | Kuno Misaki |
| Shisui | Seto Asami |
| Narration | Shimamoto Sumi |
(C) Hyuuga Natsu・Imagic Infos／”Kusuriya no Hitorigoto” Production Committee
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By Nakase Koutarou
